Rifabutin is an antibiotic that fights bacteria.

Generic Name: rifabutin (RIF a BUE tin)
Brand Name: Mycobutin

Rifabutin is used to prevent mycobacterium avium complex (MAC) in people with HIV (human immunodeficiency virus) infection.

Rifabutin is also used with other medicines to treat tuberculosis in people with HIV.

Rifabutin may also be used for purposes not listed in this medication guide.

Mycobacterium avium complex disease (disseminated) treatment in patients with HIV

Based on the US Department of Health and Human Services (HHS) Guidelines for Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV, rifabutin is an effective and recommended optional adjunctive agent in the treatment of disseminated Mycobacterium avium complex in patients with HIV.

Tuberculosis, treatment (drug-susceptible) (excludes meningitis)

Based on the ATS, CDC, and IDSA joint guidelines on the treatment of drug-susceptible tuberculosis (TB), rifabutin is recommended as a substitute for rifampin in patients who are currently receiving medications that have unacceptable interactions with rifampin or who have intolerance to rifampin.

Tuberculosis, treatment in patients with HIV

Based on the US Department of HHS Guidelines for Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV, rifabutin as part of a multidrug regimen is an effective and recommended alternative to rifampin in the treatment of TB in patients with HIV.

Tuberculosis (latent) in patients with HIV

Based on the US Department of HHS Guidelines for Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV, rifabutin is an effective and recommended alternative to rifampin in the treatment of latent TB to prevent TB in patients with HIV.